Current Funded Projects
Ionizing radiation-powered photodynamic therapy for targeted cancer treatment
The project focuses on advancing cancer treatment through the innovative approach of Ionizing Radiation-Driven Photodynamic Therapy (IR-PDT). Conventional Photodynamic Therapy (PDT) utilizes light and photosensitizing molecules (PS) to target and destroy cancerous cells. PS was shown to act as a radio-reactive molecule by enhancing generation of reactive oxygen species upon high energy irradiation. This project aims to enhance PDT by utilizing ionizing radiation, for deeper tissue penetration and more effective tumor targeting.
Laser-driven degradation of microplastic for wastewater treatment
Plastics are widely used in our daily lives due to their affordability, lightweight, strength, and durability. Unfortunately, a significant amount of plastic waste is improperly disposed of, leading to its discharge into the natural environment. When subjected to physicochemical and biological processes, plastics can degrade into smaller particles, referred to as microplastics (MPs), with dimensions less than 5 mm. The abundance and small size of MPs make them easily ingested by organisms, hindering their biological growth and causing harmful toxic effects. Humans can also experience organ damage through ingestion of MPs via the food chain or other exposure pathways. Consequently, MPs pollution has become a global concern. By using UV laser radiation, with sufficient energy to break the chemical bonds in the polymer chain, we can initiate the mechanism responsible for polymer degradation. Various initiation steps, including the use of photocatalysts, will be explored for different polymer types under different conditions.
Development of Hydrogel-based Phototheranostic Systems with Targeted Action on Breast Cancer
Plastics are widely used in our daily lives due to their affordability, lightweight, strength, and durability. Unfortunately, a significant amount of plastic waste is improperly disposed of, leading to its discharge into the natural environment. When subjected to physicochemical and biological processes, plastics can degrade into smaller particles, referred to as microplastics (MPs), with dimensions less than 5 mm. The abundance and small size of MPs make them easily ingested by organisms, hindering their biological growth and causing harmful toxic effects. Humans can also experience organ damage through ingestion of MPs via the food chain or other exposure pathways. Consequently, MPs pollution has become a global concern. By using UV laser radiation, with sufficient energy to break the chemical bonds in the polymer chain, we can initiate the mechanism responsible for polymer degradation. Various initiation steps, including the use of photocatalysts, will be explored for different polymer types under different conditions.
Advanced Laser-assisted IoT technology for cancer diagnosis
Head and neck cancer represents 5-10% of total cancer cases recorded in America and Europe, making it a significant health concern. The lack of precise delimitation of lesions in current diagnostic methods highlights the need for cancer differentiation and diagnosis techniques. By addressing these fundamental issues, the advanced laser-assisted IoT (Internet of Things) technology utilizes automated system that combines steady-state and time-resolved fluorescence, and Raman spectroscopy to allow characterization of normal and cancerous tissue. The system provides biochemical content and structural information and will improve cancer differentiation and provide accurate information for establishing tumor borders. The automated system establishes smart connectivity through the Internet of Things. This connectivity enables real-time monitoring and remote control, facilitating collaboration and accessibility for researchers and doctors. This integration of IoT enhances the overall functionality and usability of the laser-assisted technology, making it a cutting-edge solution in the field of cancer diagnosis. In addition, the project aims to create a comprehensive database containing the characterization various head and neck cancers, improving our understanding of cancer heterogeneity. In conclusion, by providing precise and reliable information through fluorescence and Raman signals, the technology has the potential to contribute to advancements in the field of oncology.
Drop coalescence - Setup for investigation of drops coalescence in view of medical applications
The Drop Coalescence Project (DROPCOAL) aims to explore how droplets coalesce and mix in the microgravity environment of the International Space Station (ISS). This research will provide valuable insights and lead to significant progress for biomedical and technological applications during long-term space missions.
The device that allow us to perform these experiments was launched on November 4, 2024, as part of SpaceX’s 31st resupply services mission. It was carried by the Dragon spacecraft from Launch Complex 39A , NASA's Kennedy Space Center in Florida. The DROPCOAL payload was installed in the ICE Cubes Facility within the European Physiology Module (EPM) Rack integrated into the Columbus module.
