Molecular structures modification of medicines exposed to laser radiation, in view of their interaction with biological materials and bicompatible fabrics
Cancer is one of the leading causes of death worldwide with approximately 14 million new cases and 8.2 million cancer-related deaths. Finding ways to diagnose and treat cancer in an early stage is of high importance since the mortality from this disease is highly influenced by its status at the time of diagnostic. One of the main directions in diagnostic pathology is to develop new methods that can provide accurate results at low costs. This project’s scope is related to the development of a label-free imaging device based on quantitative phase imaging (QPI) capable of analyzing cells within malignant or non-malignant tissues and discriminate between them by detecting slight refractive index variations of unstained tissues that are not otherwise possible with usual light microscopy techniques. The device to be developed will be composed of an interferometric set-up capable of providing quantitative information (optical pathlength/tissue density of the sample) about the tissue samples to be evaluated. This label-free method will provide an increased accuracy compared to currently employed methods by correlating the refractive index variation/distribution with the type of analyzed sample.