Current Funded Projects
Chlorpromazine loading and irradiation into hydrogels by UV laser radiation, as alternative to bacterial infected wound treatment
The number of drug-resistant bacteria is currently growing up, and the possibilities for successful treatment are narrow due to the lack of solutions in eradicating them. To overcome the emergence of multiple drug-resistant bacteria it is necessary to identify new approaches in using the existing drugs and to find ‘smart’ drug delivery systems. The discovery of compounds with direct antimicrobial effects obtained by laser irradiation of a drug is a further step in filling the gap created in antimicrobial research and represents a new approach in chemistry, biology, and pharmacology. In this respect, irradiated chlorpromazine (CPZ) proved to be an antimicrobial agent against resistant bacteria. More, conventional drug delivery methods are overwhelmed by repeated dosage of drugs and their systemic toxicity. An alternative is hydrogels that offer optimized therapeutic action of the drug and minimize the disadvantages of classical delivery method.
This proposal is addressing the use of UV laser radiation for exposure of a mixture of polymer-CPZ to form hydrogels with already irradiated CPZ in it, thus eliminating the process of CPZ separate irradiation and loading. This kind of hydrogels may be applied in wound dressing for patients that show infected wounds with various bacterial pathogens resistant to antibiotics. The project has an interdisciplinary nature, combining antimicrobial and laser spectroscopy research. It aims to provide new data on physics, chemistry, and biology of hydrogel formation and loading with drug solutions. The project’s results may have an important impact in future extensive use of laser modified compounds in medicine, pharmacology and patient care.
The project main objective is to develop and test a demonstration experimental system for water decontamination based on the action of micro and nano bubbles (micro-nanobubbles) containing reactive oxygen species such as singlet oxygen. The micro-nanobubbles include singlet oxygen and are generated by a photoactivated porous membrane containing photosensitizers functionalised carbon nanotubes and TiO2 nanoparticles.
One major side effect of nowadays abundance of plastic products is microplastic pollution, where small size polymer particles of diverse origins enter the environment, only part of them being removed by the wastewater treatment plants. This project proposal aims at developing a new laser-based device for detection of microplastics in water. The combination of the enhanced sensitivity of the Raman scattering technique obtained using very small samples (microdroplets) with the latest developments in the topics of microfluidics and optical spectroscopy may constitute an advance in the field of online monitoring of water pollutants.
The project main objective is to develop and test a chaotic technology for experimenting the methods / techniques and platforms used in encryption systems based on two synchronized ECSL chaotic laser generators, demonstration experimental system realized as an integrated, computer-controlled device (Experimental chaotic device). Within the project we start from two existing external-cavity semiconductor lasers (ECSL) systems, one with control of the chaotic emission dynamics through the injection current modulation and the other through the electro-optic phase modulation, coupled optically and with their chaotic dynamics synchronized; we will develop a hardware and software platform for an automated computer control of all sub-assemblies. So, we will able for input/output data control, so that the entire assembly becomes a device for testing the chaotic encoded techniques, as well as software platforms. The presented chaotic device aims to test and better understand basic concepts of cryptographic systems based on nonlinear chaotic dynamic of laser emission.